Our group studies Huntington’s Disease (HD), a hereditary movement disorder with dementia and behavioural difficulties. Thirty years after the discovery of the causal CAG repeat expansion mutation in the HTT gene, HD remains an incurable, devastating disorder. However, using disease models, and studies in human patients, great progress has been made in understanding the pathophysiology of HD. Research has led to the development of the novel disease modifying therapy approaches with promising results in HD model systems.
